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Conversely, for drugs where the hydroxyl group serves as the critical active site, using a OC(O)O linker is essential to fully explore the properties of 1,2-dithiolane derivatives

The critical role of the SLC46A1 encoded transporter in intestinal folate absorption is evident in individuals with an inherited form of folate malnutrition (hereditary folate malabsorption, HFM) that results from mutations in the SLC46A1 gene