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Phentermine is a Schedule IV controlled substance (DEA-classified for misuse potential), whereas semaglutide is not controlled

This implies the existence of additional plasticity mechanisms that counteract the tendency for runaway dynamics of synaptic weights introduced by the positive feedback of Hebbian-type rules

[18] Randall, V

For instance, patients with primary lesions less than 0.5 mm thick have a 10-year survival rate of 96% which decreases to 54% if the lesions are 4.01 to 6 mm thick

If results are consistent with phase 2 data, an FDA submission could follow, with potential approval expected in 2026 or 2027