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In October, a compounding industry group, the Outsourcing Facility Association, filed a lawsuit against the FDA's decision that there was no longer a shortage of tirzepatide, the active ingredient fin Zepbound and Mounjaro

The theory is straightforward: slower absorption means a gentler onset of the medication effects, reducing the sharp spike that can trigger bloating and nausea in sensitive individuals

The presence of risk factors should not automatically preclude GLP-1 agonist use but should inform monitoring strategies and patient education

Each plan provides regular virtual consultations with a clinician, prescription management and renewals (if applicable), support with insurance coverage for medications, and access to 1:1 nutritionist coaching, ongoing chat support, and health guides

The findings suggest that oral GLP-1 receptor agonists could help to widen access to therapies that reduce blood sugar and support weight loss in a market currently dominated by once-weekly injection pens

Several GLP-1 agonists have FDA approval for other indications that may overlap with BED patient populations: Semaglutide (Wegovy) and liraglutide (Saxenda) are approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity Semaglutide (Ozempic), liraglutide (Victoza), dulaglutide (Trulicity), and tirzepatide (Mounjaro) are approved for type 2 diabetes management Tirzepatide (Zepbound) is approved for chronic weight management When clinicians prescribe GLP-1 agonists for BED, this constitutes off-label use a legal and common practice in medicine when evidence suggests potential benefit and approved treatments are inadequate