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Another pre-clinical study done on C57BL/6J mice using abdominal irradiation (10 Gy) found that the expression level of miR-34a-5p in the small intestine tissue and peripheral blood significantly increased, which mediated distant cognition impairment

262 A parallel mechanism is observed in idiopathic pulmonary fibrosis (IPF), where telomere attrition in lung fibroblasts, combined with chronic inflammation and TGF- pathway activation, promotes excessive collagen deposition and irreversible structural damage

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The goal of using zonulin inhibitors is to prevent or reduce the increased permeability of the intestinal barrier associated with conditions such as leaky gut syndrome

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