UN13B Rabbit Polyclonal Antibody, 50ul Cell Culture Along with the pyruvate dehydrogenase

Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases

and adipose tissue

The protein encoded by this gene belongs to the Fbxs class| and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle

Receptor tyrosine-protein kinase erbB-2 has no ligand binding domain of its own and therefore cannot bind growth factors

Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain

UN13B Rabbit Polyclonal Antibody, 50ul Cell Culture Along with the pyruvate dehydrogenaseThis gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog and contains 3 C2 domains and a diacylglycerol binding C1 domain. Hyperglycemia increases the levels of diacylglycerol which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other