Phospho-4E-BP1 (T37) Polyclonal Antibody, 50ul Cellular Function Assays Mutations in SGCA result in

Mutations in SGCA result in type 2D autosomal recessive limb-girdle muscular dystrophy

MYLK encodes both smooth muscle and nonmuscle isoforms

The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms

and with Dejerine-Sottas syndrome (DSS)

Gene Ontology (GO) annotations related to this gene include poly(A) RNA binding and N-acetyltransferase activity

Phospho-4E-BP1 (T37) Polyclonal Antibody, 50ul Cellular Function Assays Mutations in SGCA result inEIF4EBP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV