Human Hexokinase-2, HK2 ELISA Kit, 96T Measuring Instruments By mediating lysosomal Ca(2+) release

By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed: 27787197

This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates

and is found in either a latent form composed of a mature peptide homodimer

The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors

In addition| the 70 kDa subunit binds to the osteoblast-specific transcription factors MSX2| RUNX2 and DLX5

Human Hexokinase-2, HK2 ELISA Kit, 96T Measuring Instruments By mediating lysosomal Ca(2+) releaseCatalyzes the phosphorylation of hexose, such as D glucose and D fructose, to hexose 6 phosphate (D glucose 6 phosphate and D fructose 6 phosphate, respectively) (PubMed: 23185017, PubMed: 26985301, PubMed: 29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D glucose to D glucose 6 phosphate (PubMed: 29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release