Stat4(Phospho Tyr693) Polyclonal Antibody, 100ul[BT-AP14540] Culture Tubes The BARD1/BRCA1 interaction is disrupted

The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1

are observed frequently in a variety of tumors and may contribute to tumorigenesis

Alternative splicing results in three transcript variants which differ only in the 5' UTR

The protein is implicated in several signal transduction pathways including the Stat pathway

A pseudogene of this gene is found on chromosome 1

Stat4(Phospho Tyr693) Polyclonal Antibody, 100ul[BT-AP14540] Culture Tubes The BARD1/BRCA1 interaction is disruptedThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.