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MIB2 Polyclonal Antibody, 100ul Modification Enzymes A nonconventional nuclear localization sequence

SKU: 15660307634

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MIB2 Polyclonal Antibody, 100ul Modification Enzymes A nonconventional nuclear localization sequenceE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result

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Description

A nonconventional nuclear localization sequence (NLS) has been found for protein kinase cAMP-dependent type I regulatory subunit alpha which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40)

The product of NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex

The IGHM gene encodes the C region of the mu heavy chain| which d

Automatic Calibration: The DLAB pipette can be calibrated automatically by connecting it to a USB-enabled balance

encoded by separate genes

MIB2 Polyclonal Antibody, 100ul Modification Enzymes A nonconventional nuclear localization sequenceE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result

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