UBE2K Polyclonal Antibody, 20ul Subcellular Fractions The encoded protein is predicted

The encoded protein is predicted to contain 6 to 10 transmembrane domains| and a leucine zipper motif in transmembrane domain III

This gene lies in a region of the X chromosome which has been associated with mental retardation

Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene

GAPs stimulate the intrinsic GTP hydrolysis of small G proteins

and are involved in a variety of biological processes

UBE2K Polyclonal Antibody, 20ul Subcellular Fractions The encoded protein is predictedThe protein encoded by this gene belongs to the ubiquitin conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains