Integrin Beta2 Polyclonal Antibody, 50ul[BT-AP04585] Culture Media Mutations at this locus have

Mutations at this locus have been associated with lethal congenital contractural syndrome

and it does not form homomultimers

NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing

POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed: 25642963)

it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters

Integrin Beta2 Polyclonal Antibody, 50ul[BT-AP04585] Culture Media Mutations at this locus haveITGB2 encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell surface proteins that participate in cell adhesion as well as cell surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.