TRIB3 Polyclonal Antibody, 100ul Virus Packaging Alzheimer's disease (AD) patients with

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP)

also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule)

It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes

which may be partly responsible for the protection against cell death

The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids

TRIB3 Polyclonal Antibody, 100ul Virus Packaging Alzheimer's disease (AD) patients withThe protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF kappaB. The encoded protein is a negative regulator of NF kappaB and can also sensitize cells to TNF and TRAIL induced apoptosis. In addition, this protein can negatively regulate the cell survival serine threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants.