IL-4R alpha(Phospho Tyr497) Polyclonal Antibody, 20ul Vacuum Aspirator In experiments with non-human species

In experiments with non-human species

Sclerostin (SOST) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists

Mutations in this gene cause cerebellar ataxia in humans

This protein likely localizes to the endoplasmic reticulum

Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation

IL-4R alpha(Phospho Tyr497) Polyclonal Antibody, 20ul Vacuum Aspirator In experiments with non-human speciesThis gene encodes the alpha chain of the interleukin 4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane bound protein, and this soluble form can inhibit IL4 mediated cell proliferation and IL5 upregulation by T