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Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions

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down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex

TTF-I Polyclonal Antibody, 20ul Monoclonal Antibody Preparation • Excellent performance with electronicTTF1 (transcription termination factor 1) encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TTF1. TTF1 shares the