HUWE1 Polyclonal Antibody, 50ul Sealing Film a complex that acts as

a complex that acts as a key regulator of mitosis

Interacts also with SIAH1 which promotes targeting for degradation

it binds tenaciously to poly(C)

It also interacts with and is phosphoryated by serine/threonine kinase 25

The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome

HUWE1 Polyclonal Antibody, 50ul Sealing Film a complex that acts asThis gene encodes a protein containing a C terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2 related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with