FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 50ul Cell Function Analysis The protein lacks critical active

The protein lacks critical active site residues and thus is suggested to be proteolytically inactive

the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi

as well as increased surface expression of cell activation markers

subunit:Interacts (via SH3 domain) with COL7A1

nuclear 1) gene

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 50ul Cell Function Analysis The protein lacks critical activedisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.