CD59 Polyclonal Antibody, 50ul[BT-AP01766] Organelle Studies Component of the SCF(FBXO11) complex

Component of the SCF(FBXO11) complex containing FBXO11

It is a secreted protein and may function as a homodimer

This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses| including proliferation| differentiation| and phagocytosis

As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments

Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene

CD59 Polyclonal Antibody, 50ul[BT-AP01766] Organelle Studies Component of the SCF(FBXO11) complexIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated,