CD5 Polyclonal Antibody, 50ul Buffer Solutions High mobility group box 1

High mobility group box 1 plays a role in several cellular processes

The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues

It accumulates primarily in the cytoplasm

It may be involved in regulation of cytoskeletal reorganization

not all transcripts have been fully described

CD5 Polyclonal Antibody, 50ul Buffer Solutions High mobility group box 1CD5 (also designated Lyt 1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper responsive to TCR mediated activation. CD5 associates with the TCR CD3 z chain and with the Src