UHRF1 Polyclonal Antibody, 50ul Drug Development and Evaluation A highly similar gene in

A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons

May act as a transcriptional corepressor for NK homeodomain transcription factors

The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site

An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13

This protein| which is a member of glycosyltransferase family 29| can use the same acceptor substrates as does sialyltransferase 4B

UHRF1 Polyclonal Antibody, 50ul Drug Development and Evaluation A highly similar gene inUHRF1 encodes a member of a subfamily of RING finger type E3 ubiquitin ligases. E3 ubiquitin protein ligase UHRF1binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1 S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53 dependent