Sp3/4 Polyclonal Antibody, 50ul Serological Pipets Mutations in this gene cause

Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID)

CA VIII and CA X

and at low levels in placenta

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration

It also may play a role in early intestinal development

Sp3/4 Polyclonal Antibody, 50ul Serological Pipets Mutations in this gene causeSP3 (Sp3 transcription factor) belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC and GT box regulatory elements in target genes. This protein contains a zinc finger DNA binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes.