UBS3B Polyclonal Antibody, 20ul Sampling Tubes Endoplasmic reticulum aminopeptidase 1 encoded

Endoplasmic reticulum aminopeptidase 1 encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules

including cancer and autoimmune diseases

and at a much lower levels in adipose tissue and in aorta

Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds

Higher expression levels of RPS19 in some primary colon carcinomas compared to matched normal colon tissues has been observed

UBS3B Polyclonal Antibody, 20ul Sampling Tubes Endoplasmic reticulum aminopeptidase 1 encodedThis gene encodes a protein that contains a ubiquitin associated domain at the N terminus, an SH3 domain, and a C terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet derived growth factor receptor.