TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 100ul Serological Pipets Defects in this gene are

Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3)

It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions

A germline mutation of VHL is the basis of familial inheritance of VHL syndrome

This kinase is involved in the regulation of protein synthesis

and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 100ul Serological Pipets Defects in this gene areCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only