TPC1 Rabbit Polyclonal Antibody, 20ul Apoptosis & Autophagy SLC9A3R2 (SLC9A3 regulator 2) encodes

SLC9A3R2 (SLC9A3 regulator 2) encodes a member of the NHERF family of PDZ scaffolding proteins

This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form

The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit

which is required for IL5 mediated activation of the transcription factor SOX4

Upon stimulation by inositol 1|4|5-trisphosphate| this receptor mediates calcium release from the endoplasmic reticulum

TPC1 Rabbit Polyclonal Antibody, 20ul Apoptosis & Autophagy SLC9A3R2 (SLC9A3 regulator 2) encodesVoltage gated Ca(2+) and Na+ channels have 4 homologous domains each containing 6 transmembrane segments S1 to S6. TPCN1 is similar to these channels but it has only 2 domains containing S1 to S6 (Ishibashi et al. 2000