GCM1 Rabbit Polyclonal Antibody, 20ul Bacterial Expression Defects in this gene are

Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas

pancerebellar atrophy and ataxia

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but down regulated in ovarian cancer cell lines and primary carcinomas

The DHR-2 domain is necessary for the GEF activity

GCM1 Rabbit Polyclonal Antibody, 20ul Bacterial Expression Defects in this gene areThis gene encodes a DNA binding protein with a gcm motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM motif (A G)CCCGCAT a novel sequence among known targets of DNA binding proteins. The N terminal DNA binding domain confers the unique DNA binding activity of this protein.