TCF-4/12 Polyclonal Antibody, 50ul Hepatocytes Contains 2 CBS domains

Contains 2 CBS domains

Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity

Increased expression of this gene is associated with colorectal cancer

The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes

The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor

TCF-4/12 Polyclonal Antibody, 50ul Hepatocytes Contains 2 CBS domainsTCF4 encodes transcription factor 4, a basic helix loop helix transcription factor. The Transcription factor 4 recognizes an Ephrussi box ('E box') binding site ('CANNTG') a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10 37 repeat units