CLSPN Polyclonal Antibody, 20ul RNA Synthesis RAD17 checkpoint clamp loader component

RAD17 checkpoint clamp loader component shares strong similarity with DNA replication factor C (RFC)

This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates| including members of the mitogen-activated kinase (MAPK) signalling pathway

and a C-terminal STAR-related lipid transfer (START) domain

Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined

preventing its association with target genes

CLSPN Polyclonal Antibody, 20ul RNA Synthesis RAD17 checkpoint clamp loader componentThe product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.