PPM1E Polyclonal Antibody, 100ul ROS/Nitric Oxide Detection It anchors lymphotoxin-alpha to the

It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation

including cyclic amp-response element and serum-response element

The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides

and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17

Decreased expression of this gene may play a role in the development of type 2 diabetes

PPM1E Polyclonal Antibody, 100ul ROS/Nitric Oxide Detection It anchors lymphotoxin-alpha to theThis gene encodes a member of the PPM family of serine threonine protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine threonine protein kinase PAK 1, 5' AMP activated protein kinase (AMPK) and the multifunctional calcium calmodulin dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.