p70 S6 Kinase alpha Polyclonal Antibody, 50ul[BT-AP12705] Diagnostic Probes & Oligos Mutations in this gene have

Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease

and proteins containing a conserved LXCXE motif

and its expression is upregulated in several kinds of carcinomas

Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12

p70 S6 Kinase alpha Polyclonal Antibody, 50ul[BT-AP12705] Diagnostic Probes & Oligos Mutations in this gene haveThis gene encodes a member of the ribosomal S6 kinase family of serine threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N