Cytokeratin 18 Monoclonal Antibody(2F7), 50ul Protein Post-translational Modification functions as a structural scaffold

functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS)

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Alternative splice variants encoding different isoforms have been described

The TRAF family member associated NFKB activator encoded by TANK is found in the cytoplasm and can bind to TRAF1

resulting in CaM-independent activity

Cytokeratin 18 Monoclonal Antibody(2F7), 50ul Protein Post-translational Modification functions as a structural scaffoldKRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.