SphK2(Phospho Thr614) Polyclonal Antibody, 20ul Sample Library Tubes CBL has been found to

CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA

The protein encoded by this gene is predicted to be a five-pass transmembrane protein

Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism

Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen

SphK2(Phospho Thr614) Polyclonal Antibody, 20ul Sample Library Tubes CBL has been found toThis gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1 phosphate. Sphingosine 1 phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced