BubR1 Polyclonal Antibody, 100ul 3D Culture These proteins are characterized by

These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins

Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2)

and proposed to regulate cell-cycle progression during spermatogenesis

This gene encodes a member of the nuclear hormone receptor family

The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs)

BubR1 Polyclonal Antibody, 100ul 3D Culture These proteins are characterized byBUB1B encodes a kinase involved in spindle checkpoint function. The protein (BUB1 mitotic checkpoint serine threonine kinase B)has been localized to the kinetochore and plays a role in the inhibition of the anaphase promoting complex cyclosome (APC C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.