PDX-1 Polyclonal Antibody, 100ul Sample Library Tubes The encoded protein| which belongs

The encoded protein| which belongs to the groucho/TLE family of proteins| can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes

Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS)

and the expression of this gene is a potential marker for cancer

functions as a calcium regulator in the mitochondria of skeletal muscle

Mutations in this gene as well as in its related proteins including D-type cyclins

PDX-1 Polyclonal Antibody, 100ul Sample Library Tubes The encoded protein| which belongsThe protein encoded by PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early onset insulin dependent