Phospho-B23 (T199) Polyclonal Antibody, 100ul Cellular Function Assays a transmembrane region and a

a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins

an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells

This gene is expressed in different carcinomas

May play a role in cell cycle checkpoint control

Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures

Phospho-B23 (T199) Polyclonal Antibody, 100ul Cellular Function Assays a transmembrane region and aNPM1 encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of NPM1 have been identified.