GPR143 Polyclonal Antibody, 20ul Custom DNA Oligos Mannan binding lectin serine peptidase

Mannan binding lectin serine peptidase 1 is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease

each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted

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The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation

GPR143 Polyclonal Antibody, 20ul Custom DNA Oligos Mannan binding lectin serine peptidaseGPR143 encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in GPR143 cause ocular albinism type 1, also referred to as Nettleship Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.