HSP70L Polyclonal Antibody, 100ul Culture Media They are differentially expressed in

They are differentially expressed in normal tissues

induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

An important paralog of this gene is DYNLRB1

tissue specificity:Ubiquitously expressed at low level

HSP70L Polyclonal Antibody, 100ul Culture Media They are differentially expressed inThis gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.