PLCD3 Rabbit Polyclonal Antibody, 100ul Pipette Micro Tips Mutations in this gene have

Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14

Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2)| which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades

Designed to be compatible with VT1

Mutations in PTGER2 are associated with aspirin-induced susceptibility to asthma

type I receptors phosphorylate cytoplasmic SMAD transcription factors

PLCD3 Rabbit Polyclonal Antibody, 100ul Pipette Micro Tips Mutations in this gene haveThis gene encodes a member of the phospholipase C family which catalyze the hydrolysis of phosphatidylinositol 4 5 bisphosphate to generate the second messengers diacylglycerol and inositol 1 4 5 trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for