FAK Polyclonal Antibody, 20ul[BT-AP03137] Diagnostic Probes & Oligos Mutations in this gene are

Mutations in this gene are a cause of type 2E pseudohypoaldosteronism

It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT

The protein encoded by ATR (ATR serine/threonine kinase) belongs the PI3/PI4-kinase family

shown to be a key enzyme in the terminal differentiation of keratinocytes

not all variants have been fully described

FAK Polyclonal Antibody, 20ul[BT-AP03137] Diagnostic Probes & Oligos Mutations in this gene arePTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Focal adhesion kinase 1 is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal