CUL-1 Polyclonal Antibody, 100ul[BT-AP08190] Metabolic enzymes tool compounds Periphilin 1 interacts with periplakin

Periphilin 1 interacts with periplakin

Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2)

Mutations in or deletions of the gene lead to growth hormone deficiency and short stature

and malignant cells of bone and soft tissue sarcomas

through the regulatory roles of CDK4 and p53 in cell cycle G1 progression

CUL-1 Polyclonal Antibody, 100ul[BT-AP08190] Metabolic enzymes tool compounds Periphilin 1 interacts with periplakinCore component of multiple cullin RING based SCF (SKP1 CUL1 F box protein) E3 ubiquitin protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1 F box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin conjugating enzyme. The E3