Saposin Polyclonal Antibody, 50ul Vacuum Aspirator strong ectopic expression has been

strong ectopic expression has been detected in ovarian adenocarcinoma

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype

known as the paired box

The protein encoded by this gene has homologs that have been identified in mouse| macaque| etc organisms

and an unprocessed pseudogene has been found on chromosome 10

Saposin Polyclonal Antibody, 50ul Vacuum Aspirator strong ectopic expression has beenPSAP (prosaposin) encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with