NBK(Phospho Ser35) Polyclonal Antibody, 20ul Roller Bottles The paraplegin gene is responsible

The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia

The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits

The encoded protein has a signal peptide that is cleaved to release the mature peptide

The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains| three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats

and it is the ligand for two proteins at the cell surface of T cells

NBK(Phospho Ser35) Polyclonal Antibody, 20ul Roller Bottles The paraplegin gene is responsibleThe protein encoded by this gene shares a critical BH3 domain with other death promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro apoptotic activity, and for interaction with anti apoptotic members of the BCL2 family, and viral survival promoting proteins. Since the activity of this protein is suppressed in the presence of survival promoting proteins, it is suggested as a likely target for anti apoptotic proteins.