Dok-2 Polyclonal Antibody, 50ul[BT-AP02697] Liquid Storage Consumables Tyrosine-protein kinase Fyn associates with

Tyrosine-protein kinase Fyn associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein

The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal| followed by two fibronectin type-III motifs

alpha2(VI)

No expression was seen in adrenal NCI-H295A cells or in adrenal tissue

The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop

Dok-2 Polyclonal Antibody, 50ul[BT-AP02697] Liquid Storage Consumables Tyrosine-protein kinase Fyn associates withThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.