beta -Arrestin 1(Phospho-Ser412) Rabbit Polyclonal Antibody, 20ul Drying & Desiccation This gene is located within

This gene is located within a large protease gene cluster on chromosome 16

Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases

A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon

The first exon of this gene is unrelated to immunoglobulin variable genes

This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing

beta -Arrestin 1(Phospho-Ser412) Rabbit Polyclonal Antibody, 20ul Drying & Desiccation This gene is located withinMembers of arrestin beta arrestin protein family are thought to participate in agonist mediated desensitization of G protein coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones neurotransmitters or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta adrenergic receptor kinase (BARK) mediated desensitization of beta adrenergic receptors. Besides the central nervous