EMR2 Polyclonal Antibody, 20ul[BT-AP02942] Modified Oligos Defects in TMEM237 are a

Defects in TMEM237 are a cause of Joubert syndrome-14

ABCA6 is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis

also located on chromosome 10

suggesting that they are not conventional components of the extracellular matrix

The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis

EMR2 Polyclonal Antibody, 20ul[BT-AP02942] Modified Oligos Defects in TMEM237 are aADGRE2 encodes a member of the class B seven span transmembrane (TM7) subfamily of G protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N terminal epidermal growth factor like domains coupled to a TM7 domain via a mucin like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell cell adhesion through interaction with chondroitin sulfate