FA58A Polyclonal Antibody, 20ul Supplements HCFC1 is a member of

HCFC1 is a member of the host cell factor family and encodes a protein with five Kelch repeats

Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus

Mitogen-activated protein kinase kinase kinase 3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively

This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling

Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains

FA58A Polyclonal Antibody, 20ul Supplements HCFC1 is a member ofMutations in this gene have been shown to cause an X linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin box fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.