IRE1 Alpha Monoclonal Antibody, 50ul Sealing Film The use of alternative in-frame

The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths

which thus leads to the constitutive activation of MAPK14

and may be related to tumor metastasis

and while it is not essential for the cell

This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release

IRE1 Alpha Monoclonal Antibody, 50ul Sealing Film The use of alternative in-frameThe protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum based stress signals.