CDT1 Polyclonal Antibody, 20ul Antibodies an X-chromosome recessively inherited demyelinating

an X-chromosome recessively inherited demyelinating disorder of the nervous system

Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis| membranous nephropathy and anti-glomerular basement membrane nephritis

The protein belongs to the S8P family of ribosomal proteins

which suggests that this enzyme may function in a calcium-independent manner

Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini

CDT1 Polyclonal Antibody, 20ul Antibodies an X-chromosome recessively inherited demyelinatingThe protein encoded by this gene is involved in the formation of the pre replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A dependent kinases results in degradation of the protein.