Rat Glypican 1, GPC1 ELISA Kit, 96T Human Genome Knockout Libraries Alternate transcriptional splice variants have

Alternate transcriptional splice variants have been characterized for this gene

EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation

The protein is composed of a nuclear localization domain

Biologically important in the destruction of opioid Peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed: 2966343) (By similarity)

PLAT (plasminogen activator

Rat Glypican 1, GPC1 ELISA Kit, 96T Human Genome Knockout Libraries Alternate transcriptional splice variants haveCell surface proteoglycan that bears heparan sulfate. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF