Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter MLH3 is a member of

MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes

as well as in the regulation of water excretion and cardiovascular functions

The protein localizes to cell membranes

Multiple alternatively spliced variants

We propose that human ACBD6 represents a cellular marker for primitive progenitor cells with functions in hematopoiesis and vascular endothelium development

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter MLH3 is a member ofMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.