Rb(Phospho Ser788) Polyclonal Antibody, 50ul Liquid Handling ＆Storage and Zellweger syndrome

and Zellweger syndrome

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Several transcript variants encoding different isoforms have been found for this gene

which may play a role in the response to environmental stress

neither of which is effective on its own

Rb(Phospho Ser788) Polyclonal Antibody, 50ul Liquid Handling ＆Storage and Zellweger syndromeThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.