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LIF Polyclonal Antibody, 100ul Antisense Oligonucleotides Knockout studies in mice suggest

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LIF Polyclonal Antibody, 100ul Antisense Oligonucleotides Knockout studies in mice suggestLeukemia inhibitory factor encoded by LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal fetal interface. Alternatively spliced transcript variants

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Description

Knockout studies in mice suggest that this gene plays a role in T-helper cell activation| and may be involved in inflammation and immune regulation

It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues

PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways

Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II| also known as Hunter syndrome

LIF Polyclonal Antibody, 100ul Antisense Oligonucleotides Knockout studies in mice suggestLeukemia inhibitory factor encoded by LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal fetal interface. Alternatively spliced transcript variants

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